Author : Anto Johnson, Peter


Evaluating and Mitigating the Challenges of International Students Amidst the COVID-19 Pandemic: An Overview

Daivat Bhavsar; Peter Anto Johnson; John Christy Johnson; Jasrita Singh; Austin Albert Mardon

Canadian Journal of Medicine, In Press
DOI: 10.33844/cjm.2021.60597

International students are one of the most vulnerable social groups during the COVID-19 pandemic, ignored by social and financial welfare programs. The use of statistics, governmental statements, and academic literature outline the additional hardships faced by post-secondary international students to propose interventions to reduce precarity. The hospitality of educational institutions and response programs towards international students would be crucial for upholding commitments to social justice during these challenging times. This paper can contribute to understanding the role of social work in serving groups most vulnerable to COVID-19.

An Evaluation of the Potential of Heparin to Inhibit the Viral Entry of SARS-CoV-2

Sudipta Samadder; Peter Anto Johnson; John Christy Johnson; Austin Mardon

Canadian Journal of Medicine, 2021, Volume 3, Issue Issue 3, Pages 147-152
DOI: 10.33844/cjm.2021.60513

Heparin is an anticoagulant medicine that prevents the formation of harmful blood clots in the vessels. Following the outbreak of the novel coronavirus disease 2019 (COVID-19), heparin has helped to improve the health of affected patients beyond its anticoagulant effects. The potential antiviral activity of heparin has attracted speculation due to its highly sulfated profile, which allows it to have a high binding affinity to a wide range of viral components. Heparin’s successful binding to the ZIKA virus, human immunodeficiency virus, as well as the SARS CoV and MERS CoV spike proteins have demonstrated its potential to inhibit the entry of SARS-CoV-2 into the body. A high degree of sequence homology also enables heparin to have inhibitory binding potential on viral components. The SARS-CoV-2 virus exhibits significant differences in its spike glycoprotein (SGP) sequence compared to other coronaviruses. The SGP sequence in SARS-CoV-2 contains additional potential glycosaminoglycan (GAG) binding domains that may drive differences in the attachment and entry process of the virus. Findings from unbiased computational ligand docking simulations, pseudotyped spike protein experiments, and cell to cell fusion assays have also opened possibilities to investigate the antiviral properties of heparin in clinical trials