• Register
  • Login

Canadian Journal of Medicine

  1. Home
  2. Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Related Links

FAQ

Aims and Scope

Editorial Board

Peer Review Process

Indexing and Abstracting

News

Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors

    Authors

    • Daivat Bhavsar 1
    • Yu Jun Li 2

    1 Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada; Faculty of Science, McMaster University, Hamilton, ON, Canada

    2 Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA

,

Document Type : Original Research

10.33844/CJM.2023.6029
  • Article Information
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

Genetically engineered T cells with Chimeric Antigen Receptors, CAR T cells, are a revolutionary immunotherapy used to treat advanced blood cancers. The purpose of this experiment was to model the destruction process of tumor cells with CAR T cell therapy using Complexity and Organized Behaviour Within Environmental Bounds (COBWEB), an agent-based simulation software. We designated parameter values for abiotic factors, agents (i.e. tumor cells, T cells)  and the general environment in our immunotherapy simulation model to illustrate the interactions between tumor cells and cytotoxic components, which described the binding of innate CD8+ T cells or CAR T cells to tumor antigens. The models were used to observe and comparatively analyze the rate of destruction of a solid tumor by CAR T cells and innate CD8+ T cells. The solid tumor developed in a circular island for 60 ticks, representing days; innate CD8+ or CAR T cells were then able to infiltrate the island and the tumor cell population was monitored over 500 days. The CAR T cells exhibited a significantly powerful, efficient immune response against a general solid tumor relative to the innate CD8+ T cells, yet relapse occurred in both models albeit to a lesser extent with CAR T cells. However, further investigations are required to adequately simulate the side effects and realistically-limiting factors of CAR T cell therapy. Similar comparative analyses may help measure and compare the potency of the immune response of CAR T cells compared to standard, or lack of, treatments.

Keywords

  • Cancer
  • Anti-tumor
  • Immunotherapy
  • Chimeric
  • Modeling
  • XML
  • PDF 1.01 M
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • CHICAGO
  • VANCOUVER
    • Article View: 214
    • PDF Download: 267
Canadian Journal of Medicine
Volume 5, Issue 1
April 2023
Page 24-34
Files
  • XML
  • PDF 1.01 M
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • CHICAGO
  • VANCOUVER
Statistics
  • Article View: 214
  • PDF Download: 267

APA

Bhavsar, D. and Li, Y. Jun (2023). Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors. Canadian Journal of Medicine, 5(1), 24-34. doi: 10.33844/CJM.2023.6029

MLA

Bhavsar, D. , and Li, Y. Jun. "Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors", Canadian Journal of Medicine, 5, 1, 2023, 24-34. doi: 10.33844/CJM.2023.6029

HARVARD

Bhavsar, D., Li, Y. Jun (2023). 'Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors', Canadian Journal of Medicine, 5(1), pp. 24-34. doi: 10.33844/CJM.2023.6029

CHICAGO

D. Bhavsar and Y. Jun Li, "Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors," Canadian Journal of Medicine, 5 1 (2023): 24-34, doi: 10.33844/CJM.2023.6029

VANCOUVER

Bhavsar, D., Li, Y. Jun Simulation-Based Software Modeling of CAR T Cell Therapy Efficacy Against Solid Malignant Tumors. Canadian Journal of Medicine, 2023; 5(1): 24-34. doi: 10.33844/CJM.2023.6029

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Sitemap

News

  • PubMed, a practical free resource for medical students 2022-05-23
  • Tips on rules of publishing articles in journals 2022-01-13
  • What is the BEST title for your research paper? 2021-12-29
  • On paraphrasing 2021-12-23
  • United Nations SDG Publishers Compact 2021-12-20

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

©