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Oncogenic Role of Cancer Stem Cell LGR5 in Colorectal Cancer Progression

    Authors

    • Sourena Ghorbani Kalkhajeh 1
    • Alireza Parsanezhad 1
    • Mahdieh Banoei 2
    • Maryam Vahidi 3
    • Maziar Malekzadeh Kebria 4, 5
    • Zahra Pezeshkian 5, 6
    • Noshad Peyravian 4, 5

    1 Department of Radiologic Technology, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    2 Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

    3 Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

    4 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    5 Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

    6 Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

,
10.33844/cjm.2021.60609
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Abstract

Colorectal Cancer (CRC) is the second most common cancer in women and the third most common cancer in men. There is strong evidence for the role of Cancer Stem Cells (CSCs) in cancer progression. The identification and understanding CSCs genes such as LGR5 involved in the induction of cancer development is crucial in the prognosis of CRC. LGR5 is a membrane protein involved in several molecular signaling pathways, such as the Wnt signaling and NOTCH pathways. It has been shown that the LGR5 gene was overexpressed in CRC and is associated with the worst outcomes in patients with CRC, but molecular mechanisms of LGR5 in CRC development have been poorly identified. This review has summarized current studies about the role of stem cell marker of LGR5 in CRC progression. Future research in this area may improve the early detection of CRC, new therapies, and monitoring of CRC.

Keywords

  • Cancer stem cell
  • LGR5
  • Adenoma-carcinoma sequence
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Canadian Journal of Medicine
Volume 3, Issue 4
October 2021
Page 182-190
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  • Article View: 680
  • PDF Download: 549

APA

Ghorbani Kalkhajeh, S. , Parsanezhad, A. , Banoei, M. , Vahidi, M. , Malekzadeh Kebria, M. , Pezeshkian, Z. and Peyravian, N. (2021). Oncogenic Role of Cancer Stem Cell LGR5 in Colorectal Cancer Progression. Canadian Journal of Medicine, 3(4), 182-190. doi: 10.33844/cjm.2021.60609

MLA

Ghorbani Kalkhajeh, S. , , Parsanezhad, A. , , Banoei, M. , , Vahidi, M. , , Malekzadeh Kebria, M. , , Pezeshkian, Z. , and Peyravian, N. . "Oncogenic Role of Cancer Stem Cell LGR5 in Colorectal Cancer Progression", Canadian Journal of Medicine, 3, 4, 2021, 182-190. doi: 10.33844/cjm.2021.60609

HARVARD

Ghorbani Kalkhajeh, S., Parsanezhad, A., Banoei, M., Vahidi, M., Malekzadeh Kebria, M., Pezeshkian, Z., Peyravian, N. (2021). 'Oncogenic Role of Cancer Stem Cell LGR5 in Colorectal Cancer Progression', Canadian Journal of Medicine, 3(4), pp. 182-190. doi: 10.33844/cjm.2021.60609

CHICAGO

S. Ghorbani Kalkhajeh , A. Parsanezhad , M. Banoei , M. Vahidi , M. Malekzadeh Kebria , Z. Pezeshkian and N. Peyravian, "Oncogenic Role of Cancer Stem Cell LGR5 in Colorectal Cancer Progression," Canadian Journal of Medicine, 3 4 (2021): 182-190, doi: 10.33844/cjm.2021.60609

VANCOUVER

Ghorbani Kalkhajeh, S., Parsanezhad, A., Banoei, M., Vahidi, M., Malekzadeh Kebria, M., Pezeshkian, Z., Peyravian, N. Oncogenic Role of Cancer Stem Cell LGR5 in Colorectal Cancer Progression. Canadian Journal of Medicine, 2021; 3(4): 182-190. doi: 10.33844/cjm.2021.60609

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