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Autophagy and Coronavirus Interaction: Its Significance for COVID-19 Treatment

    Author

    • Pallab Chakraborty

    University of Calcutta, India

,

Document Type : Letter to Editor

10.33844/cjm.2021.60596
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Abstract

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei province, China [1, 2]. According to the literature, the coronavirus was found to interact with autophagy pathways [3–6]. The autophagy process (recycling pathway) is very important for the degradation of cytosolic compounds and the creation of building blocks in cells [7]. During starvation conditions, this process can be activated. It delivers the cytosolic components, including the damaged cellular organelles and mis-folded proteins, into lysosomes by establishing autophagosomes, where the degradation takes place [3, 8]. It is reported to have a paradoxical role in protecting cells from viral and bacterial infections, depending on the types of pathogens and the host cells [3, 9]. Commonly known processes are xenophagy (viral particle degraded) and virophagy (degradation of neosynthesized components from virus), and innate- adaptive immune induction, by which autophagy contributes to the antiviral response [8, 10, 11].

Keywords

  • Autophagy
  • Coronavirus interaction
  • COVID-19
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Canadian Journal of Medicine
Volume 3, Issue 4
October 2021
Page 167-170
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  • Article View: 725
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APA

Chakraborty, P. (2021). Autophagy and Coronavirus Interaction: Its Significance for COVID-19 Treatment. Canadian Journal of Medicine, 3(4), 167-170. doi: 10.33844/cjm.2021.60596

MLA

Chakraborty, P. . "Autophagy and Coronavirus Interaction: Its Significance for COVID-19 Treatment", Canadian Journal of Medicine, 3, 4, 2021, 167-170. doi: 10.33844/cjm.2021.60596

HARVARD

Chakraborty, P. (2021). 'Autophagy and Coronavirus Interaction: Its Significance for COVID-19 Treatment', Canadian Journal of Medicine, 3(4), pp. 167-170. doi: 10.33844/cjm.2021.60596

CHICAGO

P. Chakraborty, "Autophagy and Coronavirus Interaction: Its Significance for COVID-19 Treatment," Canadian Journal of Medicine, 3 4 (2021): 167-170, doi: 10.33844/cjm.2021.60596

VANCOUVER

Chakraborty, P. Autophagy and Coronavirus Interaction: Its Significance for COVID-19 Treatment. Canadian Journal of Medicine, 2021; 3(4): 167-170. doi: 10.33844/cjm.2021.60596

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