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An Overview of COVID-19 Treatment: Possible Candidates Based on Drug Repurposing and Molecular Docking

    Authors

    • Mai Abdelgawad 1
    • Sahar Allam 2
    • Maha Abdelmonaem Shaheen 3
    • Mohamed Ali Hussein 4
    • Hoda Azmy Elkot 5
    • Aya A. Gaber 6
    • Khaled A. Marghany 7
    • Asmaa A. Abdelwahab 8
    • Rewan H. Alashrey 6
    • Hoda Y. Abdallah 9

    1 Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, 62511, Egypt

    2 Faculty of Medicine, Tanta University, Tanta, 31512, Egypt

    3 Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt

    4 Department of Pharmaceutical Services, 57357 Children Cancer Hospital, Cairo, 11731, Egypt

    5 Faculty of Science, Alexandria University, Alexandria, 21511,Egypt

    6 Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41511, Egypt

    7 Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41511, Egypt

    8 School of Information Technology and Computer Science, Nile University, Sheikh Zayed, Giza, 12588, Egypt

    9 Departments of Histology and Cell Biology (Genetics Unit), Faculty of Medicine, Suez Canal University, 41522, Ismailia, Egypt Center of Excellence in Molecular & Cellular Medicine, Faculty of Medicine, Suez Canal University, 41522, Ismailia, Egypt

,

Document Type : Review Article

10.33844/cjm.2021.60499
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Abstract

The current pandemic of COVID-19 is considered a worldwide threat to public health caused
by a novel type of coronaviridae family called SARS-CoV-2. Owing to the urge of finding a
treatment for this virulent virus, many aspects of drug development are swept aside. This
review aimed to clarify the double-edged sword of drug repurposing in COVID-19 via
summarizing the available treatment options and promising candidates for COVID-19 based
on drug repurposing preclinical studies and in-silico approach. Different drugs target SARS
CoV-2 main structures under clinical investigation; some showed limited efficacy and severe
side effects, while others can be promising solutions. Some drugs suppress the cytokine storm
and modulate immune response during viral infection, including anti-interleukin and
glucocorticoids. Antiparasitic agents are repurposed for SARS-CoV-2 infection management.
Various vaccines and monoclonal antibodies are designed against SARS-CoV-2 and are being
evaluated in different preclinical and clinical stages. However, none of them is approved yet.
Convalescent Plasma Transfusion is a promising strategy against SARS-CoV-2 infection,
where impressive results are reported in clinical trials, requiring more validation. Furthermore,
anticoagulant therapy exhibited better disease outcomes in patients admitted to the ICU.
Finally, in-silico studies suggested several potential compounds or FDA-approved drugs
targeting various viral structure subunits. In conclusion, although many clinical trials were
launched to examine potential therapies based on drug repurposing for COVID-19, there is no
definitive treatment till now. Moreover, computational approaches identified several
compounds and FDA-approved drugs with potential inhibitory effects.

Keywords

  • SARS-CoV-2
  • Antiviral Drugs
  • Vaccine
  • Convalescent Plasma
  • In-silico Studies
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Canadian Journal of Medicine
Volume 3, Issue 1
February 2021
Page 10-35
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  • Article View: 1,764
  • PDF Download: 1,201

APA

Abdelgawad, M. , Allam, S. , Abdelmonaem Shaheen, M. , Ali Hussein, M. , Azmy Elkot, H. , A. Gaber, A. , A. Marghany, K. , A. Abdelwahab, A. , H. Alashrey, R. and Y. Abdallah, H. (2021). An Overview of COVID-19 Treatment: Possible Candidates Based on Drug Repurposing and Molecular Docking. Canadian Journal of Medicine, 3(1), 10-35. doi: 10.33844/cjm.2021.60499

MLA

Abdelgawad, M. , , Allam, S. , , Abdelmonaem Shaheen, M. , , Ali Hussein, M. , , Azmy Elkot, H. , , A. Gaber, A. , , A. Marghany, K. , , A. Abdelwahab, A. , , H. Alashrey, R. , and Y. Abdallah, H. . "An Overview of COVID-19 Treatment: Possible Candidates Based on Drug Repurposing and Molecular Docking", Canadian Journal of Medicine, 3, 1, 2021, 10-35. doi: 10.33844/cjm.2021.60499

HARVARD

Abdelgawad, M., Allam, S., Abdelmonaem Shaheen, M., Ali Hussein, M., Azmy Elkot, H., A. Gaber, A., A. Marghany, K., A. Abdelwahab, A., H. Alashrey, R., Y. Abdallah, H. (2021). 'An Overview of COVID-19 Treatment: Possible Candidates Based on Drug Repurposing and Molecular Docking', Canadian Journal of Medicine, 3(1), pp. 10-35. doi: 10.33844/cjm.2021.60499

CHICAGO

M. Abdelgawad , S. Allam , M. Abdelmonaem Shaheen , M. Ali Hussein , H. Azmy Elkot , A. A. Gaber , K. A. Marghany , A. A. Abdelwahab , R. H. Alashrey and H. Y. Abdallah, "An Overview of COVID-19 Treatment: Possible Candidates Based on Drug Repurposing and Molecular Docking," Canadian Journal of Medicine, 3 1 (2021): 10-35, doi: 10.33844/cjm.2021.60499

VANCOUVER

Abdelgawad, M., Allam, S., Abdelmonaem Shaheen, M., Ali Hussein, M., Azmy Elkot, H., A. Gaber, A., A. Marghany, K., A. Abdelwahab, A., H. Alashrey, R., Y. Abdallah, H. An Overview of COVID-19 Treatment: Possible Candidates Based on Drug Repurposing and Molecular Docking. Canadian Journal of Medicine, 2021; 3(1): 10-35. doi: 10.33844/cjm.2021.60499

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