Cancer of Unknown Primary (CUP) is a malignant widespread metastatic disease, which primary lesion cannot be identified by exact clinical Inspection. We reported a case of metastases from cancer of unknown primary here. A 58-year-old male presented with abdominal pain, backache, weakness and weight loss. Abdominopelvic sonography of the patient revealed two heterogeneous mass lesions in the right and left of the adrenal region. The primary site of the tumor was not identified According to our evaluation. We performed brain magnetic resonance imaging (CT) for the patient that showed a very large mainly peripheral enhancing mass lesion measuring 48×37 mm in the cerebellum as Glioblastoma multiforme (GBM). We did chemotherapy with platinum-based regimens including paclitaxel and carboplatin. In this case, the clinical situation of the patient swiftly deteriorated and unfortunately before doing local treatment for the brain mass we lost our case.