Canadian Journal of Medicine

Coronavirus disease (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many systematic reviews and meta-analyses discussed the correlation of COVID-19 with a different disease. Given the urgent need for data, some meta-analyses containing datasets included many manuscripts, but their providence was not clearly reported. The possible overlap between some of the studies included in the analyses is a significant issue for conducting systematic reviews during the COVID-19 pandemic.

Cystic fibrosis (CF) is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. In this study, we performed a systematic review and meta-analysis of middle east CFTR gene mutations in CF patients to find out the most common mutations in this area. Tree mutations are common in all middle-east populations: Del 508, W1282X and N1303K which can have detection rate as high as 60.9 %.