Keywords : Meta-Analysis

Pitfalls in Interpretation of SARS-CoV-2 Infection-related Neurological Complications

Seraph Shi Kei Wu; Sunny Chi Lik Au

Canadian Journal of Medicine, 2021, Volume 3, Issue 4, Pages 176-178
DOI: 10.33844/cjm.2021.60602

Coronavirus disease (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many systematic reviews and meta-analyses discussed the correlation of COVID-19 with a different disease. Given the urgent need for data, some meta-analyses containing datasets included many manuscripts, but their providence was not clearly reported. The possible overlap between some of the studies included in the analyses is a significant issue for conducting systematic reviews during the COVID-19 pandemic.

Meta-Analysis of Prevalence of CFTR Mutations in Middle East Populations

Kazhaleh Mohammadi; Sahar Hassannejad; Arthur Saniotis; Massoud Houshmand

Canadian Journal of Medicine, 2020, Volume 2, Issue 1, Pages 1-6
DOI: 10.33844/cjm.2020.60491

Cystic fibrosis (CF) is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. In this study, we performed a systematic review and meta-analysis of middle east CFTR gene mutations in CF patients to find out the most common mutations in this area. Tree mutations are common in all middle-east populations: Del 508, W1282X and N1303K which can have detection rate as high as 60.9 %.